Initially he was not particularly successful until racing an Alfa Romeo in 1950. He came second in the championship in 1950 and won his first title in 1951

He was competing well in 1952 in a Maserati until a serious accident at Monza , Italy ended his season with a neck injury. In 1954 he was back, racing with a Maserati until Mercedes-Benz entered in mid season. Winning eight out of twelve races (six out of eight in the championship) in that year, he continued to race again with Mercedes - driving the superb W196 Monoposto - in 1955 (in a dream team that included Stirling Moss). At the end of the second successful season (which was overshadowed by disaster at Le Mans in which 81 spectators were killed) Mercedes had won all titles and withdrew from racing as nothing was left to prove.

For 1956, Fangio moved to Ferrari, replacing Alberto Ascari who had been killed in an accident, winning his fourth title - finishing first in three races and second in all the other championship races. In 1957 he returned to Maserati and won his fifth title, notable for an extraordinary performance to secure his final win at the Nurburgring in Germany . After his series of back-to-back championships he retired in 1958, after the French Grand Prix , having won 24 Grand Prix in 51 starts.

Cuban rebels kidnapped him on February 23 , 1958 but he was later freed.

During the rest of his life, he was a representative of Mercedes-Benz , often driving his former race cars in demonstration laps. In 1990 , he was inducted into the International Motorsports Hall of Fame